Cell Signaling, Biophotonic Activity and Tissue Regeneration

Signaling molecules exhibit mechanical oscillations with specific vibrational directions, playing a pivotal role in molecular electric patterns and biophoton emission, which are crucial for cellular communication and development. An intricate relationship is emerging between molecular vibrations, and endogenous biophotonic activity in shaping cellular growth, differentiation, and the intrinsic regenerative activity of tissues and organs in different animal species, including humans. Cellular microtubules, have been shown to couple mechanical and electromagnetic waves to modulate biophoton emission and cellular connectivity, acting as a bioelectronic circuit entailing memory switching capabilities at a nearly zero hysteresis loss (latency in response). Notably, exogenous photobiomodulation (the use of light to stimulate and regulate biological processes) has been shown to induce stem cell mobilization, and differentiation, telomere regeneration, wound healing, and tissue regeneration, including cardiac regeneration, and brain rescue in neurodegenerative disorders, in both experimental animal models and humans. The diffusive features of light could be exploited to target the stem cells residing in all tissue of the human body to enhance their rescuing potential and our inherent self-healing capability, without the needs for cell or tissue transplantation. The transformative potential of understanding and harnessing the biological effects of light in cellular systems may open unprecedented avenues for innovative applications in regenerative medicine, tissue engineering, and precision therapies.